Back in November I attended Build 2011.
Without a doubt the talk which stood out the most to me (and I'm sure a lot of others at the conference too) was this one by @WilsonMiner:
I was filled with inspiration as I realised that I'm insanely lucky to have the skills I have. The ability to go out and create something which I want to exist.
I think the most striking aspects of the talk were the video pieces, the music was expertly chosen to accompany the visuals and the additional voice over from Wilson just nailed it. Overall, I'd say it was the final words of the presentation that stuck with me the most:
'You know what we get to do when we leave here. We get to go make things...'
So that's exactly what I did, I went out and made GotBrief - a site to help inspire others to create things, to go out and do exactly the same: make something.
You can view all of the other talks from Build 2011 over at: http://videos.buildconf.com/access/